Motorists driving under the influence of drugs or alcohol this weekend will be targeted in checkpoints in Chula Vista, San Diego, Escondido, Oceanside and Encinitas.
Agencies declined to disclose the exact location of the checkpoints, which will begin tonight and continue through Monday night.
"If officers suspect that a driver has been drinking or is impaired, they will conduct a field sobriety test. Those who fail can expect jail, vehicle storage fees, license suspension, insurance rate increases, along with fines, fees, DUI classes, other expenses that can exceed $10,000,'' San Diego police Officer Mark McCullough said.
The weekend's checkpoints are funded by a grant from the California Office of Traffic Safety, through the National Highway Traffic Safety Administration.
City News Service contributed to this report.